Do you detect a coded meaning to this ad from the turn of the century? Though early for the use of "Mary Jane" as slang for marijuana, the "Maria Jane" reference here is paired with the unusual name "Blifkins" ("bliff" rhyming with "spliff," suggesting a cigarette of cannabis and tobacco), in the psychedelic context of "a change [coming] o'er his dreams." When we include the hallucinatory portrait in which two figures emerge from the man's face, the ad seems to be suggesting that this particular tobacco combines happily with cannabis.
